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Proc Natl Acad Sci U S A. 1998; 8(3-4):283-5. Brain Commun. Jobin C, Bradham CA, Russo MP, Juma B, Narula AS. Nat Commun. 2011 Jul; 179(1):189-98. 2006 Aug; 116(8):2058-9. 2001 Jul; 34(1):89-100. Kweon YO, Paik YH, Schnabl B, Qian T, Lemasters JJ. Bataller R, Paik YH, Lindquist JN, Lemasters JJ. Am J Physiol Gastrointest Liver Physiol. Clin Gastroenterol Hepatol. 1999 Oct 22; 274(43):30919-26. J Am Coll Cardiol. Norepinephrine induces calcium spikes and proinflammatory actions in human hepatic stellate cells. 1999 Jul; 5(4):282-93. Iwaisako K, Jiang C, Zhang M, Cong M, Moore-Morris TJ, Park TJ, Liu X, Xu J, Wang P, Paik YH, Meng F, Asagiri M, Murray LA. Floch MH, Walker WA, Sanders ME, Nieuwdorp M, Kim AS. 2008 Feb; 25(2):249-58. Development of exchange lists for Mediterranean and Healthy Eating diets: implementation in an intervention trial. 2008 Sep; 5(9):496-7. Detection of polycyclic aromatic hydrocarbon-DNA adducts in white blood cells of foundry workers. Therapeutic strategies for hepatic fibrosis. Hepatology. Hepatology. Hepatology. 1994 Sep; 17(3):410-2. NOX in liver fibrosis. 2008 Nov; 48(5):1420-9. Autocrine expression of activated transforming growth factor-beta(1) induces apoptosis in normal rat liver. Aliment Pharmacol Ther. Mutation of the 5'-untranslated region stem-loop mRNA structure reduces type I collagen deposition and arterial stiffness in male obese mice. The accuracy of patient-reported measures for GI symptoms: a comparison of real time and retrospective reports. Hepatology. 2011 Aug; 35(8):1509-18. Tumor necrosis factor-alpha induces c-jun during the regenerative response to liver injury. 1995 Jul; 22(1):241-51. 2014 Aug; 124(8):3566-78. 2015 Jan; 22(1):164-73. 1998 08; 275(2):G269-78. 2006 May; 130(6):1562. 2010 Jan 12; 107(2):844-9. Brenner married Elizabeth Slater of New York, the mother of his sons Slade and Wyatt, in the closing minutes of his David Brenner: Back with a Vengeance! HBO Special recorded in Las Vegas, on February 19, 2000. Genetic polymorphisms and the progression of liver fibrosis: a critical appraisal. 1997 Nov; 113(5):1589-98. 1992 Jun; 50(6):1203-10. 2000 Nov; 119(5):1399-401. Oncogenic Ras activates c-Jun via a separate pathway from the activation of extracellular signal-regulated kinases. 2001 Jan; 33(1):81-90. Toll-like receptors and adaptor molecules in liver disease: update. Am J Physiol. 2012; 7(4):e34218. 2008 Dec; 173(6):1617-27. 1993 May 15; 53(10 Suppl):2279-86. 1977 Dec; 60(6):1354-61. 2017 10 10; 114(41):10808-10809. 1998 Sep; 13 Suppl:S39-50. 2000 Jul; 279(1):G100-6. 1998 Oct; 27(3):192-8. Frequency of C9orf72 and SOD1 mutations in 302 sporadic ALS patients from three German ALS centers. 2017 Jun 30; 127(7):2697-2704. 2018 01; 30(1):31-38. 2003 May; 37(5):1043-55. J Hepatobiliary Pancreat Sci. Brenner succeeds Kristiina Vuori, M.D., Ph.D., who announced her intention to step down as president in January after serving in the role for the past 12 years. The future of gastroenterology and gastroenterology. Serum ?-glutamyltranspeptidase predicts all-cause, cardiovascular and liver mortality in older adults. Cox AD, Garcia AM, Westwick JK, Kowalczyk JJ, Lewis MD. Antioxid Redox Signal. NFkappaB prevents apoptosis and liver dysfunction during liver regeneration. Ann Hepatol. Infiltration of circulating myeloid cells through CD95L contributes to neurodegeneration in mice. Evidence for a common progenitor of epithelial and mesenchymal components of the liver. NADPH oxidase signal transduces angiotensin II in hepatic stellate cells and is critical in hepatic fibrosis. Metabolic Injury of Hepatocytes Promotes Progression of NAFLD and AALD. Fibrogenesis Tissue Repair. 1994 Dec 09; 269(49):30789-97. Lin A, Frost J, Deng T, Smeal T, al-Alawi N, Kikkawa U, Hunter T. NF-I/Sp1 switch elements regulate collagen alpha 1(I) gene expression. Liver: DNA methylation controls liver fibrogenesis. A Universal Gut-Microbiome-Derived Signature Predicts Cirrhosis. Reversibility of Liver Fibrosis and Inactivation of Fibrogenic Myofibroblasts. 1999 Sep 15; 163(6):3474-83. Blockade of IL-17 signaling reverses alcohol-induced liver injury and excessive alcohol drinking in mice. 2014 Aug 12; 111(32):E3297-305. PLoS One. 1998 Sep; 13(S1):S39-S50. Kagnoff MF, Omary MB, de Grandpre LY, Roebuck KA, Richman DD. PNPLA3 downregulation exacerbates the fibrotic response in human hepatic stellate cells. 2020 11; 41:101039. 2017 Jun 16; 7:314-323. Sam F, Sawyer DB, Xie Z, Chang DL, Ngoy S. Hepatic stellate cells as a target for the treatment of liver fibrosis. Fibrogenesis of parenchymal organs. 2007 Nov; 2(4):243-4. Primary cirrhotic hepatocytes resist TGFbeta-induced apoptosis through a ROS-dependent mechanism. Genetic labeling does not detect epithelial-to-mesenchymal transition of cholangiocytes in liver fibrosis in mice. J Hepatol. Decreasing fibrogenesis: an immunohistochemical study of paired liver biopsies following lamivudine therapy for chronic hepatitis B. J Hepatol. Hepatology. 2014 Dec; 26(12):1802-11. 2019 01; 17(2):218-230. Medicina (Kaunas). Gastroenterology. Gao B, Emami A, Zhou R, Lang S, Duan Y, Wang Y, Jiang L. Targeting the Wnt signaling pathway through R-spondin 3 identifies an anti-fibrosis treatment strategy for multiple organs. 1993 Feb; 17(2):287-92. Different mechanisms decrease hepatic collagen and albumin production in fasted rats. Hepatology. Proc Natl Acad Sci U S A. Gene delivery of Cu/Zn-superoxide dismutase improves graft function after transplantation of fatty livers in the rat. JCI Insight. Methods for analyzing c-Jun kinase. Gastroenterology. 2000 Dec; 32(6):1255-64. People in Profiles who have published with this person. David Brenners wife Amber confirmed her husbands passing on Friday, with fans curious to 2001 Jul 10; 104(2):221-6. Activation of activating protein 1 during hepatic acute phase response. Cell Metab. Hepatology. Migration of fibrocytes in fibrogenic liver injury. J Biol Chem. 1991 Oct; 14(4 Pt 1):740-2. Bcker U, Schottelius A, Watson JM, Holt L, Licato LL. 1994 Oct; 267(4 Pt 1):G552-61. Nat Immunol. Lehmann TG, Wheeler MD, Schwabe RF, Connor HD, Schoonhoven R, Bunzendahl H. Tumor necrosis factor alpha prevents tumor necrosis factor receptor-mediated mouse hepatocyte apoptosis, but not fas-mediated apoptosis: role of nuclear factor-kappaB. 15th International Symposium on Cells of the Hepatic Sinusoid, 2010. Combatting Fibrosis: Exosome-Based Therapies in the Regression of Liver Fibrosis. Gastroenterology. 2002 Sep; 123(3):877-8. PNAS Nexus. Gastroenterology. Deficiency of NOX1 or NOX4 Prevents Liver Inflammation and Fibrosis in Mice through Inhibition of Hepatic Stellate Cell Activation. Nat Commun. Am J Physiol Gastrointest Liver Physiol. 2021; 12(1):293-320. 2006 May; 130(6):1886-900. 2020; 15(3):e0229445. 1993 Sep; 92(3):1336-48. Gastroenterology. Traditional Chinese Medicine Fuzheng Huayu Prevents Development of Liver Fibrosis in Mice. 2011 Apr; 25(4):1133-44. 1999 09; 277(3):G671-7. Curr Pathobiol Rep. 2016 Mar; 4(1):27-35. Clin Immunol. Gastroenterology. Adachi M, Osawa Y, Uchinami H, Kitamura T, Accili D. Systemic mediators induce fibrogenic effects in normal liver after partial bile duct ligation. 1993 Apr; 264(4 Pt 1):G589-95. Alcohol Clin Exp Res. Arch Biochem Biophys. 2001 Nov; 34(5):953-63. Hepatology. 2011 Oct; 89(10):997-1013. Hepatology. Dr. David Brenner, UCSDs vice chancellor of health sciences, told the Union-Tribune, Were glad theres been a settlement. Link between gut-microbiome derived metabolite and shared gene-effects with hepatic steatosis and fibrosis in NAFLD. The role of p70S6K in hepatic stellate cell collagen gene expression and cell proliferation. Proc Natl Acad Sci U S A. 2005; 23(3-4):264-74. 2017 Feb 01; 312(2):C131-C143. Yilmaz R, Weishaupt K, Valkadinov I, Knehr A. Wastewater sequencing uncovers early, cryptic SARS-CoV-2 variant transmission. WebBrenner married Elizabeth Slater of New York, the mother of his sons Slade and Wyatt, in the closing minutes of his David Brenner: Back with a Vengeance! Enomoto N, Schemmer P, Ikejima K, Takei Y, Sato N. Mice lacking inducible nitric oxide synthase have improved left ventricular contractile function and reduced apoptotic cell death late after myocardial infarction. Hepatology. 2012 Aug 31; 337(6098):1094-7. 2017 Apr 03; 127(4):1254-1270. Proc Natl Acad Sci U S A. 1999; 8(3):151-63. The Crosstalk between Hepatocytes, Hepatic Macrophages, and Hepatic Stellate Cells Facilitates Alcoholic Liver Disease. Enomoto N, Yamashina S, Schemmer P, Rivera CA, Bradford BU, Enomoto A. IkappaBalpha gene transfer is cytotoxic to squamous-cell lung cancer cells and sensitizes them to tumor necrosis factor-alpha-mediated cell death. Mol Ther Nucleic Acids. 2012 Apr; 56(4):965-72. 2009 Sep; 50(3):929-38. 1991 12; 54(6 Suppl):1141S-1143S. Activation of Jun kinase is an early event in hepatic regeneration. 2021 09; 191(9):1564-1579. Novel association between serum pentraxin-2 levels and advanced fibrosis in well-characterised patients with non-alcoholic fatty liver disease. Growth factor inducible 14 as potential target in patients with protoporphyria I, Knehr A. Wastewater sequencing early... Rn, Srinivasan A. Porphyrias autocrine expression of activated transforming growth factor-alpha stimulates proto-oncogene c-jun expression and proliferation! 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