Medroxyprogesterone is also used to bring on a normal menstrual cycle in women who menstruated normally in the past but have not menstruated for at least 6 months and who are not pregnant or undergoing menopause (change of life). Known, suspected, or history of breast cancer. Call your doctor if you have any unusual problems while taking this medication. This activity discusses the mechanism of action, adverse effects, monitoring, and contraindications for medroxyprogesterone. Side Effects of Medroxyprogesterone. This loss of BMD is of particular concern during adolescence and early adulthood, a critical period of bone accretion. . Medroxyprogesterone is also used to prevent overgrowth of the lining of the uterus (womb) and may decrease the risk . 6. Breakthrough bleeding. Tell your doctor if any of these symptoms are severe or do not go away: changes in menstrual periods (See SPECIAL PRECAUTIONS) weight gain weakness tiredness nervousness irritability depression difficulty falling asleep or staying asleep hot flashes breast pain, swelling, or tenderness Table of Contents BOXED WARNING (What is this?) Combination HRT can rarely cause very serious side effects such as heart disease (for example, heart attacks), stroke, serious blood clots (possibly in the lungs and legs .
Breast milk secretion. (See CLINICAL STUDIES and WARNINGS, Cardiovascular disorders and Malignant neoplasms, Breast cancer.) Medroxyprogesterone is also used for endometriosis. Most people will gain 5 to 6 pounds within the first year they are on this medication. Warnings & Precautions. Medroxyprogesterone belongs to a group of medicines called progestogens, which are female hormones. When it is prescribed to help problems such as heavy, painful, irregular or missed periods, it works by replacing or supplementing the naturally produced female sex hormone called progesterone. Should any of these events occur or be suspected, estrogen plus progestin therapy should be discontinued immediately. Bone loss is greater with increasing duration of use and may not be completely reversible [see Warnings and Precautions (5.1)]. Nausea, bloating, breast tenderness, headache, change in vaginal discharge, mood swings, blurred vision, dizziness, drowsiness, or weight gain/loss may occur. WARNING: LOSS OF BONE MINERAL DENSITY Women who use Medroxyprogesterone Acetate (MPA) Injectable Suspension, USP may lose significant bone mineral density. Let your provider know if you gain a lot of weight so that you can choose an alternative together. Medroxyprogesterone may cause other side effects. Taking medroxyprogesterone (Provera) with estrogen medications can raise your risk of blood clots, which can be very dangerous and lead to a heart attack, a stroke, or a pulmonary embolism (life-threatening blood clot in the lungs). Patients should be started at the lowest dose. 1. PROVERA Warnings and Precautions (medroxyprogesterone acetate) WARNINGS See BOXED WARNINGS. Medroxyprogesterone Acetate Tablets, USP WARNING: CARDIOVASCULAR DISORDERS, BREAST CANCER AND PROBABLE DEMENTIA FOR ESTROGEN PLUS PROGESTIN THERAPY Cardiovascular Disorders and Probable Dementia Estrogen plus progestin therapy should not be used for the prevention of cardiovascular disease or dementia. Weight gain is a common side effect of medroxyprogesterone (Depo-Provera). Medroxyprogesterone should not be used to prevent heart disease, stroke, or dementia. Progestational agents have been used beginning with the first trimester Pregnancy The use of progestational drugs during the first four months of pregnancy is not recommended. Spotting (minor vaginal bleeding) Irregular periods. This warning is not based on scientific evidence. Medroxyprogesterone ACETATE Vial - Uses, Side Effects, Warnings: This medication may cause serious bone loss which may not return to normal after you stop using it. Medroxyprogesterone may also be used for purposes not listed in this medication guide. Caffeine Other medical problems combined with medroxyprogesterone acetate (MPA 2.5 mg) relative to placebo. WARNINGS AND PRECAUTIONS. The Women's Health Initiative Memory Study (WHIMS), a substudy of the WHI study, reported increased risk of developing probable dementia in postmenopausal women 65 . Warning. Medroxyprogesterone tablets are also contraindicated in patients with incomplete abortions.
Using medroxyprogesterone with any of the following may cause an increased risk of certain side effects but may be unavoidable in some cases. Immediately seek medical attention if you notice any allergic reactions such as rashes, hives, itching, difficulty breathing, swelling of your face, lips, tongue, or throat. Find everything you need to know about Depo-Provera (medroxyprogesterone injection), including what it is used for, warnings, reviews, side effects, and interactions. Medroxyprogesterone injection intramuscular (into a muscle) and medroxyprogesterone injection subcutaneous (under the skin) is used to prevent pregnancy. Common side effects of Depo-Provera include: changes in menstrual periods, weight gain, nausea, stomach cramping or pain, bloating, dizziness, headache, tiredness, drowsiness, irritability, breast tenderness, decrease in breast size, acne, hair loss, decreased sex drive, hot flashes, joint pain, or In women with hepatic dysfunction or hepatic diseases, medroxyprogesterone usage is contraindicated. The black box 1) indicates that use of DMPA for longer than 2 years may reduce peak bone mass and place a woman at increased risk of osteoporotic fracture and 2) suggests that ObGyns order bone-density assessment in women who use DMPA long-term. Learn more about Medroxyprogesterone (Oral) at . Symptoms can include: trouble breathing. Includes MedroxyPROGESTERone indications, dosage/administration, pharmacology, mechanism/onset/duration of action, half-life, dosage forms, interactions, warnings, adverse reactions, off-label uses and more. Known or suspected estrogen- or progesterone-dependent neoplasia. Allergy warning Medroxyprogesterone can cause a severe allergic reaction. Medroxyprogesterone injection is used as birth control or for treatment of cancers or endometriosis pain. Known sensitivity to DEPO-PROVERA (medroxyprogesterone acetate or any of its other ingredients). Active DVT, PE, or a history of these conditions Medroxyprogesterone (Depo-Provera) can interfere with some blood tests. Medroxyprogesterone | C22H32O3 | CID 10631 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities . It comes as three brand-name drugs: Depo-Provera, Depo-Provera Contraceptive Injection (CI), and Depo-subQ Provera 104. It is unknown if use of medroxyprogesterone acetate injectable suspension during adolescence or early adulthood, a critical period of bone accretion, will reduce peak bone mass and increase the risk for osteoporotic fracture in later life [see Warnings and Precautions (5.1)]. Before taking medroxyprogesterone: tell your doctor and pharmacist if you are allergic to medroxyprogesterone (Provera, Depo-Provera), any other medications, or corn. If any of these effects last or get. Medroxyprogesterone acetate tablets may be given in dosages of 5 or 10 mg daily for 12 to 14 consecutive days per month, in postmenopausal women receiving daily 0.625 mg conjugated estrogens, either beginning on the 1st day of the cycle or the 16th day of the cycle. Learn more about Depo-Provera . Cardiovascular Disorders An increased risk of PE, DVT, stroke, and MI has been reported with estrogen plus progestin therapy. Warnings You should not use medroxyprogesterone if you have: undiagnosed vaginal bleeding, liver disease, breast cancer, if you are pregnant, or if you have ever had a stroke or blood clot. Check with your doctor immediately if any of the following side effects occur while taking medroxyprogesterone: Incidence not known Abdominal or stomach pain absent, missed, or irregular menstrual periods anxiety blurred vision breast pain or tenderness changes in skin color chills clay-colored stools cough dark urine decrease in amount of urine . This article highlights medroxyprogesterone as it is used as contraception to prevent pregnancy. etc. The following side effects have been reported with the use of medroxyprogesterone alone: Breast tenderness. Learn about side effects, warnings, dosage, and more. Warnings Bone mineral density loss (injection) Medroxyprogesterone contraceptive injection may cause significant loss of bone mineral density. Also, it highlights the important role that providers play in administering medroxyprogesterone and regularly monitoring patients for side effects. MEDROXYPROGESTERONE (DEPOPROVERA, PROVERA) reviews: Side effects, use, dosage (), warnings, interactions, mechanism of action (moa), brand names: Depo-Prov. Bone loss is greater with increasing duration of use and may not be completely reversible. Warnings You should not use medroxyprogesterone if you are pregnant, or if you have liver disease, a hormone-related cancer such as breast or uterine cancer, a history of stroke or blood clot, or abnormal vaginal bleeding that has not been checked by a doctor. Medroxyprogesterone acetate is contraindicated in women with any of the following conditions: Undiagnosed abnormal genital bleeding.
Some of the serious side effects of Medroxyprogesterone are: Shortness of breath Chest pain Coughing Blood clots Stroke Seizure Frequent urination Medroxyprogesterone can cause some serious side effects and can lead to some serious health problems. The risk of bone loss. . [US Boxed Warning]: Medroxyprogesterone contraceptive should not be used as a long-term birth control method (ie, longer than 2 years . Serious side effects of Medroxyprogesterone include: fever pain or swelling in legs or hands weakness jaundice chest pain, cough, rapid breathing Additionally, as stated in a boxed warning on medroxyprogesterone depot injections, medroxyprogesterone usage can alter the bone mineral density and . Medroxyprogesterone is sometimes used with another medication (a type of estrogen) as combination hormone replacement therapy (HRT) in women after menopause. Amenorrhea (absence of menstrual periods) Vaginal secretions. Medroxyprogesterone warnings This drug comes with several warnings. What Are Warnings and Precautions for Medroxyprogesterone? WARNINGS 1. Medroxyprogesterone may cause side effects. Warnings & Precautions. Find everything you need to know about Medroxyprogesterone (Oral), including what it is used for, warnings, reviews, side effects, and interactions. It's injected by a healthcare provider. If used together, your doctor may change the dose or how often you use medroxyprogesterone, or give you special instructions about the use of food, alcohol, or tobacco. PROVERA Boxed Warning (medroxyprogesterone acetate) WARNING: CARDIOVASCULAR DISORDERS, BREAST CANCER AND PROBABLE DEMENTIA FOR ESTROGEN PLUS PROGESTIN THERAPY Cardiovascular Disorders and Probable Dementia Estrogen plus progestin therapy should not be used for the prevention of cardiovascular disease or dementia. Loss of bone mineral densityUse of medroxyprogesterone acetate injectable suspension reduces serum estrogen levels and is associated with significant loss of bone mineral density (BMD). If you are facing any of the above serious side effects. Before using medroxyprogesterone injection: tell your doctor and pharmacist if you are allergic to medroxyprogesterone (Depo-Provera, depo-subQ provera 104, Provera .
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